Opportunity Information: Apply for PA 18 784
The funding opportunity titled "The Mechanistic Role of the Microbiome in the Pathobiology of Heart, Lung, Blood, and Sleep Diseases (R01 - Clinical Trial Not Allowed)" (PA-18-784) is an NIH research grant solicitation focused on explaining how the human microbiome actually works in the context of heart, lung, blood, and sleep (HLBS) health and disease. The central emphasis is not simply describing which microbes are present, but identifying functional and causal mechanisms: the molecular, immunological, and physiological pathways through which microbial communities and microbial products influence host biology. It explicitly includes microbiota from multiple body sites, particularly the gut, lung, and oral cavity, and it recognizes that the microbiome is broader than bacteria alone, encompassing viral and fungal members as well. The overall intent is to generate actionable, mechanistic knowledge that can support early translational thinking for improved understanding and eventual treatment of HLBS conditions in both adults and children, while keeping the work in the non-clinical-trial space.
This FOA encourages projects designed around hypothesis-driven mechanistic studies that can show how microbiome components modulate or activate specific host pathways relevant to HLBS phenotypes. Appropriate approaches include in vitro, in vivo, and ex vivo experimental systems, meaning applicants can use controlled cell-based systems, animal models, organoids, tissue explants, or other experimental platforms suited to dissecting cause-and-effect relationships. The common thread is that the work should move beyond association and into function: identifying microbial factors (such as metabolites, structural components, secreted molecules, or community interactions) and demonstrating how they alter immune responses, inflammation, barrier function, metabolic signaling, circadian and sleep-related pathways, cardiopulmonary physiology, hematologic processes, or other relevant biological circuits that plausibly drive health or pathology.
The FOA is framed to support multidisciplinary research teams, reflecting how complex microbiome-host interactions are and how many technical and conceptual skill sets are required to unravel mechanisms. It specifically encourages collaborations spanning fields such as cardiology, pulmonology, hematology, sleep science, circadian biology, immunology, omics-related sciences, microbiology, microbial ecology, biotechnology, and bioinformatics. In practice, that language signals that applications are expected to integrate rigorous microbiome measurement with equally rigorous host-phenotype biology, and to use analytic methods capable of linking microbial features to mechanistic readouts rather than producing purely descriptive microbiome profiles.
The award mechanism is an R01 research project grant, and the solicitation is labeled "Clinical Trial Not Allowed," which means applicants should not propose studies that meet NIH’s definition of a clinical trial. While human-derived samples, observational human cohort data, or studies that inform translational directions may be relevant, the funded work under this FOA is intended to center on mechanistic experimentation rather than interventional testing in human participants. The opportunity is categorized as a discretionary grant in the health area and is associated with CFDA numbers 93.233, 93.837, 93.838, and 93.839, reflecting alignment with NIH and the broader HLBS mission space.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when specified in the listing); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also calls out a wide range of institution types as explicitly included, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies, indicating an interest in broad participation across the research ecosystem.
Foreign eligibility is nuanced. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the primary applicant organization. However, non-domestic components of U.S. organizations may participate, and foreign components, as defined in the NIH Grants Policy Statement, are allowed. In other words, the lead applicant must be an eligible domestic entity, but international collaborations can be incorporated through allowable foreign components when scientifically justified.
Administrative details provided in the source data include the opportunity number PA-18-784, an original posting/creation date of 2018-05-14, and an original closing date listed as 2021-09-07. The source data does not specify an award ceiling or an expected number of awards, which typically means applicants would need to consult the full NIH program announcement and related institute guidance for budget expectations, paylines, or institute-specific constraints. Overall, the opportunity is best understood as an NIH-supported pathway for mechanistic, experimentally grounded microbiome research aimed at clarifying how microbial ecosystems and their products shape HLBS biology in ways that could inform future diagnostics, preventions, or therapies, without proposing a clinical trial as part of the application.Apply for PA 18 784
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Mechanistic Role of the Microbiome in the Pathobiology of Heart, Lung, Blood, and Sleep Diseases (R01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839.
- This funding opportunity was created on 2018-05-14.
- Applicants must submit their applications by 2021-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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