Opportunity Information: Apply for RFA CE 22 009

This CDC funding opportunity (RFA CE 22 009) supports investigator-initiated research focused on evaluating real-world, community-based prevention approaches that intentionally connect two goals: reducing substance use and overdose, and addressing adverse childhood experiences (ACEs) by preventing new ACEs and lessening the harms of past ACE exposure. The CDCs National Center for Injury Prevention and Control (NCIPC) is looking for projects that do more than describe a program; applicants are expected to carry out rigorous evaluation that includes both process evaluation (how the approach is implemented, for whom, under what conditions, and with what level of fidelity and reach) and outcome evaluation (whether the approach produces measurable changes related to substance use, overdose, and ACEs-related outcomes). The broader idea behind the announcement is that trauma and adversity in childhood are closely tied to later substance use risk, and communities are increasingly implementing strategies that span the social ecology (individual, family, school, neighborhood, systems) to address these interconnected problems at the same time.

A major reason for the funding is that many jurisdictions are already integrating ACEs-related components into overdose prevention work, but there is still limited high-quality evidence about what works best at the community level and why. NCIPC notes that a substantial share of its Overdose Data to Action (OD2A) recipients are implementing overdose prevention activities that either support people with ACE histories or try to prevent ACEs alongside substance use and overdose prevention. Similar integrated strategies are also being supported through other NCIPC efforts. CDC frames these as early steps toward cross-cutting, integrated prevention frameworks, and this grant is meant to build the evaluation evidence needed to identify effective models that communities can replicate, adapt, and scale.

Applicants are expected to base the prevention strategies being evaluated on the best available evidence for preventing substance use, overdose, and ACEs. The emphasis is not on inventing an untested program from scratch, but on rigorously evaluating approaches that are being implemented within communities and that have a plausible evidence base. Because the work happens in real settings, CDC highlights that strong partnerships will be necessary: the applying institution will need to collaborate with outside entities to carry out the strategy and the evaluation. To strengthen community buy-in and feasibility, CDC strongly encourages partnerships with state health departments or other CDC-funded recipients already implementing related NCIPC strategies (examples named include OD2A, NACCHO ACEs prevention, PACED2A, and EfC), or with communities that can demonstrate they have the capacity to implement these kinds of prevention approaches. Competitive applications are expected to show that the evaluators and the implementing community partners have a solid working relationship and clear roles, ideally building on established relationships with communities already doing ACEs-related activities and/or substance use and overdose prevention. Even if a relationship is not already in place, CDC still strongly encourages applicants to partner with communities that are already implementing these strategies.

The award mechanism is a cooperative agreement, meaning CDC anticipates substantial involvement and collaboration during the project period rather than a hands-off grant. The opportunity is listed under CFDA 93.136 and is categorized as a discretionary health funding opportunity. Eligibility is broad and includes governmental entities (state, county, city/township, special districts), public and private institutions of higher education, tribal governments and tribal organizations, public housing authorities, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (including small businesses), and other entities as clarified in the full announcement. The posting indicates an expected six awards, with an award ceiling of $831,250. The opportunity was created December 10, 2021, with an original closing date of February 21, 2022, and electronic applications were due by 5:00 pm ET on the due date.

In practical terms, this opportunity is aimed at building credible, actionable evidence about integrated community prevention frameworks that link trauma-informed and ACEs-prevention strategies with overdose and substance use prevention. CDC is signaling that the field has promising activity underway across the country, but the next step is to rigorously measure implementation and outcomes so decision-makers can identify which combinations of strategies are effective, feasible, and sustainable in community settings.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Rigorous Evaluation of Community-Level Substance Use and Overdose Prevention Frameworks that Incorporate ACEs-Related Prevention Strategies" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
  • This funding opportunity was created on Dec 10, 2021.
  • Applicants must submit their applications by Feb 21, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $831,250.00 in funding.
  • The number of recipients for this funding is limited to 6 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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