Opportunity Information: Apply for RFA CE 22 009
This CDC funding opportunity (RFA CE 22 009) supports investigator-initiated research focused on evaluating real-world, community-based prevention approaches that intentionally connect two goals: reducing substance use and overdose, and addressing adverse childhood experiences (ACEs) by preventing new ACEs and lessening the harms of past ACE exposure. The CDCs National Center for Injury Prevention and Control (NCIPC) is looking for projects that do more than describe a program; applicants are expected to carry out rigorous evaluation that includes both process evaluation (how the approach is implemented, for whom, under what conditions, and with what level of fidelity and reach) and outcome evaluation (whether the approach produces measurable changes related to substance use, overdose, and ACEs-related outcomes). The broader idea behind the announcement is that trauma and adversity in childhood are closely tied to later substance use risk, and communities are increasingly implementing strategies that span the social ecology (individual, family, school, neighborhood, systems) to address these interconnected problems at the same time.
A major reason for the funding is that many jurisdictions are already integrating ACEs-related components into overdose prevention work, but there is still limited high-quality evidence about what works best at the community level and why. NCIPC notes that a substantial share of its Overdose Data to Action (OD2A) recipients are implementing overdose prevention activities that either support people with ACE histories or try to prevent ACEs alongside substance use and overdose prevention. Similar integrated strategies are also being supported through other NCIPC efforts. CDC frames these as early steps toward cross-cutting, integrated prevention frameworks, and this grant is meant to build the evaluation evidence needed to identify effective models that communities can replicate, adapt, and scale.
Applicants are expected to base the prevention strategies being evaluated on the best available evidence for preventing substance use, overdose, and ACEs. The emphasis is not on inventing an untested program from scratch, but on rigorously evaluating approaches that are being implemented within communities and that have a plausible evidence base. Because the work happens in real settings, CDC highlights that strong partnerships will be necessary: the applying institution will need to collaborate with outside entities to carry out the strategy and the evaluation. To strengthen community buy-in and feasibility, CDC strongly encourages partnerships with state health departments or other CDC-funded recipients already implementing related NCIPC strategies (examples named include OD2A, NACCHO ACEs prevention, PACED2A, and EfC), or with communities that can demonstrate they have the capacity to implement these kinds of prevention approaches. Competitive applications are expected to show that the evaluators and the implementing community partners have a solid working relationship and clear roles, ideally building on established relationships with communities already doing ACEs-related activities and/or substance use and overdose prevention. Even if a relationship is not already in place, CDC still strongly encourages applicants to partner with communities that are already implementing these strategies.
The award mechanism is a cooperative agreement, meaning CDC anticipates substantial involvement and collaboration during the project period rather than a hands-off grant. The opportunity is listed under CFDA 93.136 and is categorized as a discretionary health funding opportunity. Eligibility is broad and includes governmental entities (state, county, city/township, special districts), public and private institutions of higher education, tribal governments and tribal organizations, public housing authorities, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (including small businesses), and other entities as clarified in the full announcement. The posting indicates an expected six awards, with an award ceiling of $831,250. The opportunity was created December 10, 2021, with an original closing date of February 21, 2022, and electronic applications were due by 5:00 pm ET on the due date.
In practical terms, this opportunity is aimed at building credible, actionable evidence about integrated community prevention frameworks that link trauma-informed and ACEs-prevention strategies with overdose and substance use prevention. CDC is signaling that the field has promising activity underway across the country, but the next step is to rigorously measure implementation and outcomes so decision-makers can identify which combinations of strategies are effective, feasible, and sustainable in community settings.Apply for RFA CE 22 009
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Rigorous Evaluation of Community-Level Substance Use and Overdose Prevention Frameworks that Incorporate ACEs-Related Prevention Strategies" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Dec 10, 2021.
- Applicants must submit their applications by Feb 21, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $831,250.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQ)
What is this CDC funding opportunity?
This opportunity is CDC RFA CE 22 009, a discretionary health funding announcement (CFDA 93.136) that supports investigator-initiated research to evaluate community-based prevention approaches that connect two goals: (1) reducing substance use and overdose and (2) addressing adverse childhood experiences (ACEs) by preventing new ACEs and reducing harms from past ACE exposure.
What is the main purpose of the grant?
The main purpose is to build high-quality, actionable evidence about what works at the community level when substance use/overdose prevention is intentionally integrated with ACEs prevention and trauma-informed approaches. CDC is looking for rigorous evaluations that can help communities replicate, adapt, scale, and sustain effective models.
Which CDC center is leading this opportunity?
The opportunity is led by CDCs National Center for Injury Prevention and Control (NCIPC).
What kinds of projects is CDC looking for?
CDC is looking for projects that evaluate real-world, community-based prevention approaches operating across the social ecology (for example, at the individual, family, school, neighborhood, and systems levels) and that explicitly link overdose/substance use outcomes with ACEs-related prevention and harm reduction goals.
Is this grant meant to fund the creation of a brand-new program?
No. The emphasis is not on inventing an untested program from scratch. Applicants are expected to evaluate approaches that are already being implemented in communities and that are grounded in the best available evidence for preventing substance use, overdose, and ACEs.
What does CDC mean by evaluating an approach in "real-world" community settings?
CDC is emphasizing evaluation of strategies as they operate in actual communities (not just controlled or purely academic settings), where implementation conditions vary and partnerships, feasibility, reach, and fidelity can affect results.
What type of evaluation does CDC expect?
CDC expects rigorous evaluation that includes both:
- Process evaluation: how the approach is implemented, for whom, under what conditions, and with what level of fidelity and reach.
- Outcome evaluation: whether the approach produces measurable changes related to substance use, overdose, and ACEs-related outcomes.
What is meant by "process evaluation" in this announcement?
Process evaluation refers to documenting and analyzing implementation, including how the strategy is delivered, who it reaches, how consistently it is delivered as intended (fidelity), the conditions that support or hinder delivery, and the circumstances under which it works best.
What is meant by "outcome evaluation" in this announcement?
Outcome evaluation refers to measuring whether the strategy is associated with measurable changes in outcomes tied to substance use, overdose, and ACEs-related outcomes.
Why is CDC funding this area now?
CDC notes that many jurisdictions are already integrating ACEs-related components into overdose prevention work, but there is still limited high-quality evidence about what works best at the community level and why. This grant is intended to close that evidence gap.
How does CDC connect ACEs with substance use and overdose?
The announcement reflects the idea that childhood trauma and adversity are closely tied to later risk for substance use, and that communities are increasingly implementing strategies that address these interconnected issues together.
Does CDC expect applicants to describe a program, or to evaluate it?
CDC expects more than a description. Applicants are expected to carry out a rigorous evaluation that can credibly inform decisions about effectiveness, feasibility, and sustainability in community settings.
Are partnerships required or encouraged?
Strong partnerships are highlighted as necessary because the work is conducted in real settings. The applying institution is expected to collaborate with outside entities to carry out both the prevention strategy and the evaluation.
Who are the recommended partners for competitive applications?
CDC strongly encourages partnerships with state health departments or other CDC-funded recipients already implementing related NCIPC strategies, including examples such as OD2A, NACCHO ACEs prevention, PACED2A, and EfC, or with communities that can demonstrate capacity to implement these prevention approaches.
Do applicants need to have an existing relationship with community partners?
Competitive applications are expected to show that evaluators and implementing community partners have a solid working relationship and clear roles, ideally building on established relationships. However, CDC also strongly encourages partnering with communities already implementing these strategies even if the relationship is not already in place.
What does CDC mean by "integrated" prevention approaches?
In this announcement, integrated approaches intentionally connect overdose/substance use prevention with ACEs prevention and trauma-informed components, aiming to address both current substance use and overdose risks and the underlying and ongoing impacts of childhood adversity.
What is the award mechanism for this opportunity?
The award mechanism is a cooperative agreement, which means CDC anticipates substantial involvement and collaboration with recipients during the project period rather than a hands-off grant relationship.
What does "substantial involvement" mean in a cooperative agreement?
Based on the announcement summary, it means CDC expects active collaboration during the project period. (Specific operational details would be defined in the full announcement.)
Who is eligible to apply?
Eligibility is broad and includes governmental entities (state, county, city/township, special districts), public and private institutions of higher education, tribal governments and tribal organizations, public housing authorities, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (including small businesses), and other entities as clarified in the full announcement.
How many awards does CDC expect to make?
The posting indicates an expected six awards.
What is the maximum award amount?
The award ceiling listed is $831,250.
What is the CFDA number for this opportunity?
The opportunity is listed under CFDA 93.136.
When was the opportunity posted, and what was the deadline?
The opportunity was created on December 10, 2021. The original closing date was February 21, 2022, and electronic applications were due by 5:00 pm ET on the due date.
What kinds of outcomes are relevant to this grant?
Outcomes relevant to this grant include measurable changes related to substance use, overdose, and ACEs-related outcomes, consistent with the integrated goals of the announcement.
How does this opportunity relate to OD2A and other NCIPC efforts?
NCIPC notes that many OD2A recipients are implementing overdose prevention activities that support people with ACE histories or aim to prevent ACEs alongside overdose and substance use prevention. Similar integrated strategies are supported through other NCIPC efforts, and this grant is intended to strengthen the evaluation evidence base for such approaches.
What is CDC hoping to produce through these funded evaluations?
CDC is signaling a need for credible, actionable evaluation findings that help identify which combinations of integrated strategies are effective, feasible, sustainable, and suitable for replication, adaptation, and scaling in community settings.
Does CDC specify the levels or settings where strategies should operate?
Yes. The announcement references strategies spanning the social ecology, including individual, family, school, neighborhood, and systems levels, reflecting a community-wide approach.
What makes an application competitive based on the summary provided?
Based on the information provided, competitive applications are expected to (1) evaluate an approach with a plausible evidence base, (2) conduct rigorous process and outcome evaluation, and (3) demonstrate strong partnerships with clear roles and a solid working relationship with implementing community partners, ideally in communities already doing ACEs-related and/or overdose/substance use prevention activities.
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