Opportunity Information: Apply for RFA DK 27 119
The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) funding opportunity (RFA-DK-27-119) is a National Institutes of Health (NIH) program run through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that supports P30 center grants focused on digestive and liver diseases. The basic idea is to strengthen and accelerate research by building an organized “core center” that serves a community of investigators at an institution. Rather than funding a collection of unrelated projects, this program funds shared resources (cores), services, and an administrative structure designed to make existing digestive and liver disease research more collaborative, efficient, and productive. Clinical trials are optional under this NOFO, meaning an application can include clinical-trial-related activities if appropriate, but it is not required.
A key feature of the DDRCC model is the emphasis on a clear, unifying central theme. Each center must be organized around a theme that reflects the major focus of the participating investigators’ ongoing digestive and/or liver disease research. That theme must fall squarely within the NIDDK mission and cannot be primarily in an area where another NIH Institute or Center would typically be the main funder. In practice, this means applicants need to show that the proposed center is not only scientifically coherent, but also strategically aligned with NIDDK’s portfolio and priorities in digestive and liver diseases. The center structure is meant to bring together both basic and clinical investigators, improving communication across disciplines and creating a pipeline for new ideas, new collaborations, and more impactful studies.
The funding supports the “core concept,” where multiple investigators share access to centralized facilities, specialized technologies, services, expertise, and coordination that would be inefficient or too costly for individual labs or projects to maintain on their own. These shared resources are intended to increase synergy across the institution’s digestive and liver disease research community, raise overall scientific quality, and reduce duplication. The expectation is that the DDRCC will be a hub that enables investigators to do better science faster by providing cost-effective, high-value infrastructure, rather than acting as a standalone research project.
Eligibility is tightly linked to the strength of the institution’s existing research base in digestive and/or liver diseases that matches the proposed theme. Only institutions with a strong, already-funded program of relevant research are eligible. Specifically, the institution must demonstrate at least $3 million per year in direct costs supporting research within the proposed theme area, and that theme area must be one of primary interest to NIDDK. The qualifying research base can include a mix of federal and private support, including research career development awards, but there is an important NIDDK commitment requirement: at least 30 percent of the total research base funding counted toward eligibility must come from NIDDK. Also, the research base must include enough federally funded awards to meet a utilization requirement for cores: each Biomedical Research Core must be used by at least two federally funded center members. Certain award types do not count toward the research base calculation, including training grants, education grants, and fellowships. In addition, facilities and administration (F&A, or indirect costs) must be excluded from the research base total because indirect cost rates vary substantially by institution; only direct costs are counted.
This opportunity is classified as discretionary funding and uses the grant mechanism, with a health-related activity category and CFDA number 93.847. A wide range of domestic applicant organizations are listed as eligible in the general eligibility field, including various levels of government, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others. At the same time, the NOFO makes clear that the practical eligibility threshold is the presence of a sufficiently large, ongoing, theme-aligned digestive and/or liver disease research base, with the specified NIDDK share and federal utilization requirements for cores.
International participation is not allowed in the form of applicant organizations or components. Non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not permitted. In other words, applications must be fully domestic in terms of organizational structure and performance sites/components under the award.
From a funding and timeline standpoint, the NOFO lists an expected four awards, an award ceiling of $750,000, and an original application due date of February 10, 2027. The opportunity was created on June 16, 2026. Overall, this program is aimed at institutions that already have a substantial, NIDDK-relevant digestive or liver disease research ecosystem and want to formalize and strengthen that ecosystem through shared cores and center-level organization that expands collaboration, boosts productivity, and catalyzes new research directions.Apply for RFA DK 27 119
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2026-06-16.
- Applicants must submit their applications by 2027-02-10.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) (RFA-DK-27-119)
What is the DDRCC funding opportunity (RFA-DK-27-119)?
The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) opportunity (RFA-DK-27-119) is an NIH program run through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports P30 center grants focused on digestive and liver diseases.
What does a P30 DDRCC award fund?
This program funds shared resources ("cores"), services, and an administrative structure that support a community of investigators at an institution. It is designed to strengthen and accelerate existing digestive and/or liver disease research by making it more collaborative, efficient, and productive.
Does this program fund individual research projects?
No. The DDRCC model is not meant to fund a collection of unrelated research projects. Instead, it funds center-level infrastructure such as shared facilities, specialized technologies, services, expertise, coordination, and administration that enable investigators to do better science faster and more cost-effectively.
What is meant by the DDRCC "core concept"?
The core concept means multiple investigators share access to centralized facilities and services that would be inefficient or too costly for individual labs or projects to maintain alone. These shared resources are intended to increase synergy, improve scientific quality, and reduce duplication across an institution's digestive and liver disease research community.
Is there a required scientific theme for a DDRCC?
Yes. Each DDRCC must have a clear, unifying central theme that reflects the major focus of participating investigators' ongoing digestive and/or liver disease research.
How should the DDRCC theme align with NIH and NIDDK priorities?
The theme must fall within the NIDDK mission and cannot be primarily in an area where another NIH Institute or Center would typically be the main funder. Applicants are expected to show the proposed center is scientifically coherent and strategically aligned with NIDDK's digestive and liver disease portfolio.
Is the DDRCC intended to bring together basic and clinical researchers?
Yes. The center structure is meant to bring together both basic and clinical investigators, improve communication across disciplines, and support a pipeline for new ideas, collaborations, and impactful studies.
Are clinical trials required under this funding opportunity?
No. Clinical trials are optional under this Notice of Funding Opportunity (NOFO). Applications may include clinical-trial-related activities if appropriate, but clinical trials are not required.
What institutions are practically eligible to apply?
Practical eligibility depends on having a sufficiently large, ongoing, theme-aligned digestive and/or liver disease research base that meets the NOFO's funding and utilization thresholds (including specific requirements for NIDDK-supported funding and core utilization by federally funded members).
What is the minimum research base required to be eligible?
The institution must demonstrate at least $3 million per year in direct costs supporting research within the proposed theme area, and that theme area must be one of primary interest to NIDDK.
Do indirect costs (F&A) count toward the $3 million research base threshold?
No. Facilities and Administration (F&A), also called indirect costs, must be excluded from the research base total. Only direct costs are counted because indirect cost rates vary substantially by institution.
Does the research base have to be entirely federally funded?
No. The qualifying research base can include a mix of federal and private support, and it may include research career development awards. However, there is an NIDDK commitment requirement that must be met.
What is the NIDDK commitment requirement for eligibility?
At least 30 percent of the total research base funding counted toward eligibility must come from NIDDK.
Are there award types that do not count toward the research base calculation?
Yes. Certain award types do not count toward the research base calculation, including training grants, education grants, and fellowships.
Is there a federal utilization requirement tied to Biomedical Research Cores?
Yes. The research base must include enough federally funded awards to meet a utilization requirement for cores: each Biomedical Research Core must be used by at least two federally funded center members.
What kinds of activities are DDRCC shared resources expected to support?
The shared resources are expected to provide centralized facilities, specialized technologies, services, and expertise, along with coordination that improves collaboration and productivity for investigators working in digestive and/or liver disease research aligned to the center's theme.
What is the funding type and mechanism for this opportunity?
This opportunity is classified as discretionary funding and uses the grant mechanism. It is a health-related activity, with CFDA number 93.847.
How many awards does the NOFO expect to make?
The NOFO lists an expected four awards.
What is the award ceiling listed in the NOFO?
The NOFO lists an award ceiling of $750,000.
When is the application due date?
The original application due date is February 10, 2027.
When was this funding opportunity created?
The opportunity was created on June 16, 2026.
Are non-U.S. (international) organizations eligible to apply?
No. Non-U.S. entities are not eligible to apply.
Can a U.S. organization include a non-U.S. component under this award?
No. Non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not permitted. Applications must be fully domestic in organizational structure and components/performance sites.
What domestic organization types are listed as eligible in the general eligibility field?
The general eligibility field lists a wide range of domestic applicants, including various levels of government, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others.
If many organization types are listed as eligible, why is eligibility described as "tightly linked" to the existing research base?
Because the NOFO sets a practical eligibility threshold: the applicant institution must already have a substantial, theme-aligned digestive and/or liver disease research ecosystem, including at least $3 million per year in direct-cost research support within the theme, at least 30 percent of that research base from NIDDK, and sufficient federally funded awards to support required core utilization.
What is the overall goal of the DDRCC program?
The program aims to help institutions with strong, NIDDK-relevant digestive or liver disease research formalize and strengthen that ecosystem through shared cores and center-level organization that expands collaboration, boosts productivity, reduces duplication, and catalyzes new research directions.
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