Opportunity Information: Apply for PAS 19 392
The NIH, within the Department of Health and Human Services, is offering a discretionary grant opportunity under PAS-19-392 titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Basic Science (R03 Clinical Trials Not Allowed)." This is an R03 small research grant mechanism intended to fund important, innovative, and focused basic science projects that investigate the neurodegenerative mechanisms and biological pathways involved in Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). While the emphasis is on foundational, mechanistic work rather than human intervention studies, the longer-term expectation is that the knowledge generated will help move the field toward better prevention strategies, improved diagnostic approaches, more effective treatments, and/or stronger models of care for people affected by AD/ADRD.
A central purpose of this program is workforce and field development. It is designed to help build and strengthen the pipeline of researchers in the United States who are pursuing research and academic careers in neuroscience, AD/ADRD, and healthy brain aging. At the same time, it also aims to attract established investigators who have expertise in other areas but are not currently working in AD/ADRD, by supporting pilot studies that allow them to pivot into Alzheimer’s and related dementia research. In practice, that means the program is positioned to fund smaller, early-stage or proof-of-concept studies that can generate preliminary data, validate a novel idea, or open a new research direction that can later be scaled into a larger AD/ADRD research program.
The announcement is explicitly limited to basic science and states that clinical trials are not allowed, signaling that proposed work should not involve prospective assignment of human participants to interventions to evaluate health-related outcomes. Instead, applicants are expected to focus on laboratory, preclinical, computational, or other mechanistic approaches that can clarify how disease processes start, progress, or interact with aging and other risk factors. Although the solicitation text is brief, the framing suggests NIH is looking for projects that are both scientifically rigorous and creative, with a clear line of sight to eventual translational relevance even if the immediate work is foundational.
In terms of funding parameters, the opportunity lists an award ceiling of $100,000 and anticipates around 12 awards. The program falls under the NIH health funding activity category and is associated with CFDA number 93.866. The opportunity was created on October 7, 2019, and the original closing date is listed as November 16, 2022, which is important for applicants to verify in current NIH systems whether the notice is still active, has been reissued, or has transitioned to a related funding announcement.
Eligibility is broad and includes a wide range of organizations that commonly apply for NIH research funding. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than higher education institutions); for-profit organizations other than small businesses; small businesses; and other entities as described in the additional eligibility text referenced in the notice. The announcement also reiterates NIH’s standing encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities, aligning the program with broader NIH goals around inclusive participation in the biomedical research enterprise.
Overall, this opportunity is best understood as a targeted, small-grant entry point into AD/ADRD basic science. It supports projects that can quickly test ideas, establish feasibility, and produce the kind of early evidence needed to justify larger future studies, while simultaneously strengthening the next generation of researchers and inviting new investigators into the Alzheimer’s and related dementia research space.Apply for PAS 19 392
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Basic Science (R03 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Oct 07, 2019.
- Applicants must submit their applications by Nov 16, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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|---|
| Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Archiving and Leveraging Existing Data Sets for Analyses (R03 Clinical Trial Not Allowed) Apply for PAS 19 391 Funding Number: PAS 19 391 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $100,000 |
| Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Systems Biology (R03 Clinical Trial Not Allowed) Apply for PAS 19 393 Funding Number: PAS 19 393 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $100,000 |
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