Opportunity Information: Apply for PAR 19 248
This National Institutes of Health (NIH) funding opportunity, PAR-19-248, supports R01 research projects aimed at improving the usefulness of animal models for studying human immunity to influenza infection and influenza vaccination. The central goal is to make animal models more closely mirror how the human immune system responds to influenza so that results from preclinical studies are more reliable when predicting what will happen in people. A strong emphasis is placed on boosting the predictive value of these models specifically for testing and advancing next-generation and universal influenza vaccine approaches, where translation from animals to humans has often been a major scientific bottleneck.
The FOA is focused on basic and translational research to either refine existing influenza animal models or develop entirely new ones that better recapitulate human immune responses. In practical terms, this could involve improving how animals are exposed to influenza virus, adjusting vaccination regimens to better match human dosing or schedules, incorporating clinically relevant endpoints, or building models that capture key human immunological features such as prior exposure history, immune imprinting, age-related immune differences, or mucosal immunity. The overarching expectation is that applicants will propose well-justified model improvements that address known gaps between animal and human influenza immunity and that can ultimately provide a stronger evidence base for selecting vaccine candidates and vaccination strategies for human testing.
This is an R01 mechanism (a standard NIH Research Project Grant) and is explicitly labeled "Clinical Trial Not Allowed," meaning the work should not involve NIH-defined clinical trials in humans. The activity category is Health, and the listing is associated with CFDA number 93.855. The opportunity is discretionary and uses the grant funding instrument type.
A wide range of applicant organizations are eligible. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with 501(c)(3) status (and nonprofits without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal government agencies; faith-based or community-based organizations; non-domestic (non-U.S.) entities (foreign organizations); regional organizations; Indian/Native American tribal governments other than federally recognized ones; and U.S. territories or possessions. This broad eligibility is designed to encourage participation from many sectors and institution types, including those that serve underrepresented communities and organizations outside the United States.
Key administrative details provided in the source data include an FOA creation date of April 11, 2019, and an original closing date listed as June 10, 2021. The stated award ceiling is $500,000, indicating the opportunity anticipates projects at or below that upper budget level. The source data lists "ExpectedAwards:" but does not provide a specific number, so the exact anticipated award count is not specified in the excerpt.
Overall, the FOA is best understood as a targeted NIH effort to strengthen the preclinical foundation for influenza vaccine development by funding research that makes animal models more human-relevant immunologically. By improving how well animal studies predict human immune protection and vaccine performance, this program is intended to reduce the risk of late-stage failures and accelerate progress toward broadly protective or universal influenza vaccines.Apply for PAR 19 248
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Projects to Improve the Predictive Value of Animal Models in Recapitulating Human Immunity to Influenza Infection and Vaccination (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2019-04-11.
- Applicants must submit their applications by 2021-06-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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